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When oxidative damage accumulates again to a certain level, ferroptosis is also induced in these originally adjacent cells, which continues to lead to a reduction in the antioxidant capacity of surrounding cells, ultimately leading to large areas of pRTECs damage

FGF FGF proteins secreted by tumour stromal cells interact with FGF receptors (FGFRs) on cancer cells, resulting in enhanced cancer cell growth [408]

The initial model was rigid-body fitted into the consensus EM density map via UCSF Chimera 1.14 32 , followed by manual adjustment using ISOLDE 33 embedded in UCSF ChimeraX 1.6 34