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This induction is significantly attenuated in Nrf2-deficient keratinocytes, indicating that 4-HNEs effects are mediated, at least in part, through the Nrf2 pathway [45]
doi: 10.1016/j.bbagen.2012.09.008 80 MartinovM
As red blood cells pass through these partially occluded vessels, they are sheared, resulting in schistocytes on peripheral blood smear and microangiopathic hemolytic anemia
