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The effect on truly "stubborn" subcutaneous fat (which is resistant due to higher alpha-2 adrenergic receptor density) is unclear

The concentration was 50 to 100 times lower than standard GHK-Cu serums (0.02% vs 1 to 2%), which likely explains the modest outcome

If you've been consistent with daily dosing, proper reconstitution, and refrigerated storage, and still see zero change at 16 weeks, the issue is likely absorption or individual receptor sensitivity rather than insufficient dose

Am J Physiol Endocrinol Metab (2012) 303:E334351
