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This reaction is an expected side effect

Table of Contents: What is Vitamin B12

They might also see redness or swelling, or feel a bit of itching or rash

It is supposed that antidepressants such as tricyclic antidepressants or the serotonin norepinephrine reuptake inhibitors may be involved in the reinforcement of the descending inhibitory pathways by increasing the amount of norepinephrine and serotonin in the synaptic cleft at both supra-spinal and spinal levels [11]
