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Under prolonged metabolic stress, it may progress to metabolic-associated steatohepatitis (MASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma, which are among the leading causes of end-stage liver disease and liver transplantation

Ghiam MK, et al
This indicates the presence of a more sophisticated and complex central-peripheral interactive regulatory network (Kowalska and Brown, 2007

10.1016/j.ecoenv.2016.07.036 94 RushtonP
