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Unlike platinum-induced mitochondrial dysfunction, vincristine may alter mitochondrial Ca 2+ signal transduction [5, 6] and promote signal expression in the process of inducing oxidative damage (including NOX1, NOX2 and iNOS), leading to oxidative stress of sciatic nerve tissue, and antioxidants such as HO-1 and NQO-1 are highly decreased [28]

doi: 10.3389/fphar.2015.00323 Received 13 October 2015 Accepted 30 December 2015 Published 19 January 2016 Volume 6 - 2015 Edited by Hibah Omar Awwad, University of Oklahoma Health Sciences Center, USA Reviewed by Javier Angulo, Hospital Ramn y Cajal, Spain

Zheng Y, Jin D, Lin J, Zhang Y, Tian J, Lian F, et al