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28 Wnt signaling was associated with carriage of the A allele of the rs2069502 CDK4 SNP (including a 1.5-fold change in expression of -catenin, a primary modulator of WNT signaling and a concomitant 1.4-fold change in expression of TCF4 , a developmental transcription factor that is a downstream target of WNT (Table 4, Supplementary Figure S4)

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