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10.1016/j.brainres.2005.01.098 Brain Res

Other documented adverse effects include decreased appetite (which contributes to the therapeutic effect), fatigue, injection site reactions, dizziness, and modest increases in heart rate (typically 2-4 beats per minute)

Furthermore, OS from hyperglycemia may promote -cell dysfunction and reduce insulin secretion by cells (13, 31)

This has established it as a "gold standard" ingredient in skin whitening and brightening products
