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however, this enzyme may be retarded in Flavin insufficient states due to the fact that the second step in its pathway requires FAD for dimethyl glycine (DMG) HCY de-methylation and without sufficient FAD, DMG accumulates and the BHMT betaine degradation pathway is stalled (87)
Furthermore, Six of the studies which clarified high amount of folate might be a protective factor for CRC in all three MTHFR C677T genotype, especially in TT genotype
doi: 10.1016/j.mito.2017.08.001
