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[PubMed: 2744760] 283

Discussion We have reviewed a growing body of preclinical and clinical studies conducted over the past two decades that have examined the development and efficacy of IN CNS therapeutics

Inhibition of immune checkpoints and vascular endothelial growth factor as combination therapy for metastatic melanoma: an overview of rationale, preclinical evidence, and initial clinical data

Moreover, long-term safety should be explored to assess the feasibility of using herbal extracts as a long-term therapeutic option
