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When local expression of IGF-1 was blocked by the binding of Wnt induced secreted protein 3 (WISP3), a protein involved in cell differentiation, IGF-1-induced collagen X expression was also reduced [211]
The molecular machinery that governs these processes is extensively regulated by post-translational modifications, which couple mitochondrial morphology to intracellular signaling pathways and help fine-tune mitochondrial responses based on the cells functional state [44]
doi: 10.1111/acel.13109
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