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It is possible that circulating IGF-II after release from the ternary complex is cleared from the circulation by binding to the IGF2R identical to the mannose-6-phosphate receptor which is associated with lysosomes and results in degradation of IGF-II in endothelial cells (23)

This review article provides an overview of our current understanding of chondroinductive peptides for treating OA-affected cartilage and explores the delivery systems used for regeneration

Food Res Intern 150:110746

[Google Scholar] 5.Pizzorno J
