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The SURPASS-3 MRI substudy added another layer, showing tirzepatide actually reduced muscle fat infiltration across all doses, indicating improved muscle quality even as total muscle volume decreased
The review also highlights the relevance of the MM environment, focusing on the importance of the bone marrow (BM) niche
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The mechanisms of FA-induced insulin resistance have been intensively studied and have been attributed to two metabolites of FAs - DAGs and ceramides
