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C3d was first used as an adjuvant in 1996, with 2 or 3 copies of recombinant C3d delivered alongside the model antigen HEL, drastically increasing antibody responses by up to 10,000-fold (145)
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The ringlike pattern was more common in males than females
Bei den meisten Betroffenen stoppt die Erkrankung allerdings innerhalb eines Jahres
