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In brief, when TrkB and p75 NTR co-express in the same cells, p75 NTR enhances neurotrophin binding to TrkB, augmenting both ligand affinity and selectivity, hence, reinforcing the TrkB-mediated trophic response via up-regulation of PI3K/Akt and/or IRAK/NF-B signaling 3

Wright CJ, Rentschler KM, Wagner NT, Lewis AM, Beggiato S, Pocivavsek A (2021) Time of day-dependent alterations in hippocampal kynurenic acid, glutamate, and GABA in adult rats exposed to elevated kynurenic acid during neurodevelopment

Khavinson V, Linkova N, Diatlova A, Trofimova S