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The separate counting of small colonies (slowly growing, indicative of chromosome mutations) and large colonies (fast growing, indicative of gene mutations) also showed no significant increase in the number of colonies (absolute numbers) upon treatment with MA or EA (6487 small colonies upon treatment with 535 g MA, 7284 upon treatment with the same doses of EA, neither one of them dose-related, compared with 83 and 75 in the vehicle controls, respectively

in TCC, GSTP1 should be considered as a potential therapeutic target This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access 183,71 per year only 15,31 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

In recent GLP-1RA trials focusing on patients with obesity, favourable effect on worsening heart failure in HFpEF patients was indicated to be modulated by baseline BMI [32], although the underlying mechanisms that explain the cardiovascular and renal benefits may not necessarily be due to weight loss alone