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[133] In 2014, Michael Spiteller (Technische Universitt Dortmund) and collaborators reported results, also in Angewandte Chemie , that supported the conclusion that the presence of tramadol in those tree roots was the result of tramadol having been ingested by humans and having been administered to cattle (by farmers in the region)

Phase I Activation The liver breaks down toxins into reactive intermediates through oxidation, reduction, and hydrolysis reactions

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Once these foreign substances enter systemic circulation, they trigger a massive, full-body immune response