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These effects typically relate to reduced food intake and caloric adaptation

Pierre: Many people have been speculating that we will need annual boosters for the COVID vaccines, and we have good precedents of other types of vaccines that require an annual booster

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Clin Endocrinol 40:383391 Hansen TB, Brixen K, Vahl N, Jrgensen JO, Christiansen JS, Mosekilde L, Hagen C (1996) Effects of 12 months of growth hormone (GH) treatment on calciotropic hormones, calcium homeostasis, and bone metabolism in adults with acquired GH deficiency: a double blind, randomized, placebo-controlled study