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Figure 6A), a natural coumarin isolated from Cullen corylifolium (L.) Medik

However, Gid12, rigidly affixed to Gid4 and Gid5, would partially occupy the space between Gid4 and the RING domains and could limit substrate accessibility of a bulky substrate to a ubiquitylation active site

The immunosuppressive function of M2 macrophages aids tumor immune evasion and progression, indirectly reducing ferroptosis sensitivity
