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At 75mg daily, most protocols observe metabolic effects within 24 weeks

Methylmalonyl-CoA Mutase : Converts methylmalonyl-CoA into succinyl-CoA in the Krebs cycle, supporting neuronal energy metabolism
It may be used as a diagnostic measure to identify the cause of the fluid accumulation, for example, infection, gout, or rheumatoid arthritis, or as a therapeutic intervention to relieve pressure and discomfort

A randomized, double-blind, placebo-controlled study of oral AOD9604 in overweight adults