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10.1038/nm.4409 [DOI] [PubMed] [Google Scholar] 34

Thus, it can be concluded that high-intensity exercises often have a negative effect on the integrity of the intestine, whereas low- and moderate-intensity regular exercise can have a positive effects

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Consequently, while existing therapeutic strategies show promise in pre-clinical models, significant challenges such as organ specificity, potential off-target effects, and inter-individual metabolic variability must be addressed prior to clinical translation