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International union of basic and clinical pharmacology

Osteoarthritis is common in older people and considered the leading cause of frequent joint pains

Chronic fatigue syndrome is more common in women than in men and is prominent among people between the ages of 25 and 45, with a few exceptions

Representative drugs like the highly selective HIF-2 antagonist Belzutifan (MK-6482) [488] inhibit the expression of pro-angiogenic and pro-survival genes, alleviating abnormal metabolic burden and vascular disruption in tumor tissues
