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However, clinical human trials are still limited

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PCa cells and stromal components sustain a hypermetabolic state characterized by heightened dependence on glutamine and mTORC1-mediated suppression of autophagy, a process critical for oncogenesis, as evidenced by dysregulated autophagy-related genes (e.g., STK11/LKB1) upstream of mTORC signaling (198)

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Techniques include ablation and excision, with evidence indicating that compared to diagnostic laparoscopy alone, laparoscopic surgery probably increases viable intrauterine pregnancy rates in women with minimal to mild endometriosis (OR 1.89, 95% CI 1.25 to 2.86

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10.1146/annurev.phyto.022508.092135 Annu

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