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For tirzepatide, clinicians use the official prescribing information for the specific product and indication
Following cellular uptake via endocytosis or phagocytosis, MNPs can disrupt membrane integrity and induce mitochondrial and lysosomal dysfunction, which activate inflammation-related signaling pathways, including NF-B and the NLRP3 inflammasome [31,32]

Vitiligo: A Possible Model of Degenerative Diseases
We next examined the Zn 2+ -dependent proteome of AH and screened it for the proteins capable of mediating cytotoxic signals of zinc, among which pigment epithelium-derived factor (PEDF) was the most relevant candidate