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3-Bromopyruvate inhibits glycolysis, depletes cellular glutathione, and compromises the viability of cultured primary rat astrocytes
Inside the cell, the -glutamyl amino acid is hydrolyzed by -glutamyl cyclo-transferase and converted into oxoproline and a free amino acid
However, reports that relate antibody titres to disease progression involve relatively few patients 86,87,88 , and are confounded by the higher levels of antigen seen in severe infections that are predicted to drive a stronger immune response or a heightened innate inflammatory response
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