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Additionally, GPxs due to their subcellular compartmentalization (cytoplasmic, membrane, ER, and mitochondrial localizations) control the local concentration gradient of peroxides and thereby regulate the activation/deactivation of redox-responsive signaling pathways [1, 8,9,10]
We also showed that MG initially depletes bacterial GSH levels and activates gshF gene expression, resulting in higher GSH levels for the wild-type bacteria but not for the glyoxalase mutants that are unable to recycle GSH used for MG detoxification
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This method helps the vitamin stay in the body longer
