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Douglas (1975)
Many patients find that rotating injection sitesalternating between the abdomen, thigh, and upper armprevents irritation buildup in a single location and allows local inflammation to resolve fully before reusing that site
doi: 10.1093/humupd/dml016
This suggests communication between the immune system and dopamine is crucial in shaping effort allocation as a function of peripheral immunometabolic states (aging, obesity, etc.)
