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Furthermore, given the fact that danger signals often change multiple times in lipid metabolism, developing more potent activators/inhibitors that target multiple FAO signaling pathways, including the CPT system or combined with other anti-inflammatory/antitumor therapeutics, may facilitate translation of this promising strategy into clinical application

That means clinicians and users rely heavily on mechanistic insight and clinical experience to manage the issue

These results indicate that B12 deficiency affects the levels of the cytokines in AT and circulation, thus inducing pro-inflammatory factors which could contribute to adipose dysfunction