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Closing: challenges and opportunities The classic motor symptoms of PD result from selective degeneration of dopaminergic neurons in the SNpc, and subsequently the disruption of key motor control circuits

tuberculosis infection, and GSH has been shown to enhance this

Furthermore, neuroprotective and disease-modifying agents, including histone deacetylase 6 (HDAC6) inhibitors and metabolic regulators like metformin, show mechanistic promise but face challenges such as poor solubility, rapid clearance, non-specific distribution, and low brain bioavailability 17,18,19,20

H 2 O 2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response