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Closing: challenges and opportunities The classic motor symptoms of PD result from selective degeneration of dopaminergic neurons in the SNpc, and subsequently the disruption of key motor control circuits

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tuberculosis infection, and GSH has been shown to enhance this

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Furthermore, neuroprotective and disease-modifying agents, including histone deacetylase 6 (HDAC6) inhibitors and metabolic regulators like metformin, show mechanistic promise but face challenges such as poor solubility, rapid clearance, non-specific distribution, and low brain bioavailability 17,18,19,20

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H 2 O 2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response

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