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Means and variances (SDS) were extracted for each measure to calculate effect sizes

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These tiny spicules create tiny pricks in the surface of the skin that allow active ingredients to penetrate deeper into the dermis, maximising the effectiveness of the other, powerful ingredients in this product, as well as the ingredients in the rest of your skincare routine

Results and Discussion The manuscript discusses the mechanism of action of potential compounds (natural and pharmacologically synthesized), and other advance approaches that could efficiently modulate mitochondrial machinery in terms of regulating mitochondrial biogenesis, mitophagy, bioenergetics pathways, oxidative stress, calcium homeostasis and mitochondrial DNA stability