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Mitochondrial Metabolic Research: Evaluating peptide influence on cellular energy production pathways
The Mayo Clinic notes that while the recommended daily amount for adults is 2.4 micrograms, higher doses have been found to be safe

Patients with a history of cobalt allergy may be at increased risk, as all cobalamins (including hydroxocobalamin and cyanocobalamin) contain a cobalt atom in their molecular structure

Liu J, Hanley AJG, Young TK, Harris SB, Zinman B
