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doi:10.1016/j.tox.2022.153136

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Mutations in the DCHS1 gene, encoding a member of the cadherin superfamily involved in cell-cell adhesion molecules, have been identified as causing myxomatous MVP ( DSP , HCN4 , MYH6 , and TTN ), in favor of a common genetic origin for both myocardial and MV disease ( TTN encodes for the giant sarcomeric protein titin and is regarded the cause of 25% of familial dilated cardiomyopathy

[DOI] [PubMed] [PMC] Zhou Y, Tian N, Li P, He Y, Tong L, Xie W
