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The cytosolic presence of ESAT-6 is implicated in the activation of the NLRP3 inflammasome complex, including ASC and caspase-1, a process instrumental for the liberation of IL-1 ( Figure 2 ) (32)
It is possible that the LKB1/AMPK/ACC pathway is activated by direct redox modulation of cellular proteins since activation of AMPK pathway has been directly linked to cellular redox status and hydrogen peroxide 49
In addition, liver-specific FGF4 knockout mice were more prone to accumulate lipid peroxides and free iron, leading to more severe liver damage and inflammation
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