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Additional studies have shown early damage in the neuropil, with degenerative and hypertrophic changes, and axonal degeneration, with preservation of neurons

Kornbluth RS, Kee K, Richman DD: CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta-chemokines

The following section summarizes the physicochemical and pharmacokinetic properties of these alkaloids as they may relate to the risk of kratom-drug interactions in humans
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