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The prevalence per million individuals in the United States and incidence per million live births are 0.36 and 0.57 for RDEB-sev gen, 0.14 and 0.30 for RDEB-O, and 1.49 and 2.12 for DDEB, respectively.[140] The clinical manifestations demonstrate a continuum of severity that complicates definitive diagnosis, especially early in life

The cytosolic side of the pit is coated with the protein clathrin, which stabilizes the pit

As a result, more ROS and RNS are produced by the mitochondria

This basal layer consists of columnar cells anchored to the basement membrane via hemidesmosomes and anchored to the dermis via penetrating fibrils (see Fig