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Impact of gut microbiome on skin health: gut-skin Axis observed through the lenses of therapeutics and skin diseases

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We speculate that this may be because diets with Lys/Met ratios of 3:1 and 2:1 promote the expression of lipolysis-related genes

Aberrant hypermethylation of promoter regions results in gene silencing, either by preventing transcription factor binding or by facilitating the recruitment of repressor complexes, whereas hypomethylation may inappropriately activate normally silenced genes, thereby promoting genomic instability and dysregulated gene expression [110]