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In PDAC, heme synthesis was identified as an in vivo vulnerability in metabolism-focused in vivo CRISPR screens [39, 40], and higher expression of a heme synthesis signature correlated with lower disease-free survival [39]

17 (1_suppl): S23S29

Given that there may be similar immune mechanisms responsible that underpin both tumour control and irAEs, researchers were concerned initially that steroids or other immunosuppressive agents to control irAEs would also hinder tumour control

Metabolic Effects and Hypoglycemia Risk As an insulin-like peptide, IGF-1 DES can lower blood glucose through enhanced glucose uptake, insulin-mimetic effects, improved insulin sensitivity, but risk of hypoglycemia at high doses
