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After ALA administration in mice and in accordance with the increased content of brain ALDH2 mRNA, we detected increased ALDH2 activity in brain homogenates
doi: 10.1016/j.arr.2021.101263 9 MehannaRJankovicJ
These findings have important implications since they can affect the nature of the study design, sample size, statistical power considerations and dose selection for therapeutic applications which is achieved by the biphasic concentration regulation with respect to MLE and other hormetic mixtures
Anyone considering this treatment should discuss the pros and cons with their doctor
