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Immunohistochemistry and immunofluorescence staining both revealed that GSDMD was predominantly localized to supporting cells (SCs) within the organ of Corti, particularly pillar cells and Claudius cells, with minimal expression in hair cells (HCs) (Fig

What makes 5-Amino-1MQ interesting is its ability to block NNMT, an enzyme that rises in obesity and aging

In conclusion, OA pathogenesis is propelled by a metabolically dysregulated milieu, where obesity, oxidative stress, gut dysbiosis, and broader metabolic syndrome converge to create a self-perpetuating cycle of inflammation and tissue damage (Figure 1)

Administering iodine containing contrast agents can have noxious effects on the microbiota by binding to the amino acids tyrosine and histidine on the bacterial membrane, as well as by oxidation of cytoplasmic and membrane components [4]
