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That Cdk4,6 inhibitors have significant off-target activities (Hafner et al., 2017) raises the possibility that these cancer therapies can be improved by a new class of drugs targeting cyclin substrate recognition and helix-based docking

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[DOI] [PMC free article] [PubMed] [Google Scholar] [363].Wen YR, Tan PH, Cheng JK, Liu YC, Ji RR, Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance, J