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No differences in glutathione reductase activity and content of reduced glutathione, oxidized glutathione, and oxidized/reduced glutathione ratio were seen after 12 months of supplementation with omega3 PUFAs

If SAM pools remain elevated due to reduced NNMT activity, downstream methylation pathways could theoretically be affected

12 This can cause batch-to-batch variation, and the exact characterization of species present in dosage can be tedious leading to complex pharmacokinetics (PK) after systemic administration