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Description
Though considered rare, some people have reported anaphylactic responses

Relationship of folate, vitamin b-6, vitamin b-12, and methionine intake to incidence of colorectal cancers

North America 1

The first reaction is catalyzed by tryptophan hydroxylase (TPH-1), which requires L-tryptophan, tetrahydrobiopterin (BH4), and O 2 as co-substrates, and has ferrous ion (Fe 2+ ) as an activator
