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These responses involve the coordinated upregulation of antioxidant genes, glutathione S-transferase (GST ), catalase (Cat), glutathione-peroxidase (GPxs), hemeoxygenase1 (HO-1) and peroxiredoxins (Prdxs), to lessen the oxidative load and restore cellular homeostasis

Mouse models show a clear size-dependent pattern of toxicity

The transition to resolution is promoted by macrophage efferocytosis of dying neutrophils, characterized by a time and context-dependent phenotypic M2 polarized switch, toward repair and resolution

Entomol Gen 39(34): 221230 Zhao JZ, Collins HL, Li YX, Mau RFL, Shelton AM (2006) Monitoring of diamondback moth (Lepidoptera: Plutellidae) resistance to Spinosad, Indoxacarb, and Emamectin Benzoate