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[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Norwitz NG, Feldman D, Soto-Mota A, et al

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After the establishment of the dopamine positive reinforcement theory of addiction in the 1970s, multiple nondopaminergic systems have been proposed to play a role in alcohol addiction such as the endogenous opioid positive reinforcement and corticotropinreleasing hormone negative reinforcement theories (Herz, 1997