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In addition, short-term administration of rhIGF-1 has been shown to increase glomerular filtration rate and renal plasma flow in patients with end-stage renal disease and in healthy subjects

[DOI] [PubMed] [Google Scholar] 136.Bhongade ML, Tiwari IR

Small amounts of bilirubin can be produced from intravascular hemolysis as well (see image below), but most of the bilirubin in a hemolytic anemia with an intravascular component is due to the concurrently occurring extravascular hemolysis (this is because most of the free hemoglobin, which is liberated into plasma with intravascular hemolysis, ends up being lost in the urine versus being converted to bilirubin in macrophages)