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ROS also decrease the activity of histone deacetylase (HDAC) which recoil DNA of the histone core to stop transcription, 36,37 and probably increase the activity of Histone acetyltransferase, which uncoils DNA from the histone core to allow transcription
Drug Des Devel Ther 9:24852499 Ilic S, Drmic D, Zarkovic K et al (2010) High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats
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