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It suppresses the production of T helper-1 (Th1) cytokines (IL2 and IFN) and Th2 cytokines (IL4 and IL10), reduces costimulatory molecule activity (CD28 on CD4 + T cell, the co-receptor B7-1 activity in macrophages and dendritic cells), inhibits NFkB activation, which is a key transcription factor involved in T cell receptor-mediated signaling, and downregulates inducible MHC (major histocompatibility complex) class II expression

(4) Peter J Apel, Jian Jun, Michael Callahan, Casey N Northam, et al (2010) Effect of Locally Delivered IGF-1 on Nerve Regeneration During Aging: An Experimental Study in Rats Muscle Nerve, 2010 Mar, Volume 41 (Issue 3), Pages 335341

By cleansing H O , a byproduct of thyroid hormone production, GPX enzymes protect the thyroid gland from OS [48]

Also using lion's mane is another great one