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Biochemistry 13 , 28052812 (1974)

Finally, although we followed a predefined protocol and used standardized tools for quality and risk-of-bias assessment, subjective judgment in study selection, data extraction, and interpretation cannot be entirely excluded

This is why B12 is often linked to cognitive function, memory, and even mood regulation

Most CpG sites in the human genome are methylated, with the exception of CpG-rich regions, which are typically located near transcription start sites and are associated with promoter regions, known as CpG islands
