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Although there have been no clinical reports on the use of chili peppers in the treatment of ADHD, its active compounds (CAP, vitamin C, omega-3 PUFAs) have been shown to affect the gut microbiota and its metabolites (see Table 1)

Most studies were brief and used dosages within the upper consumption limits, even though no significant adverse effects were documented in the supplementation trials that were part of this analysis

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Using Parkin-null (Park / ) flies, a study showed that folic acid supplementation improved the motor dysfunction and decreases hydrogen peroxide and glutathione redox imbalance [175] where as in fly homozygous for Parkin mutation (c00062), folic acid supplementation improved the mortality, locomotory defect, oxidative stress by alleviating mitochondrial dysfunction associated with Parkin mutation [176]