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Few recent studies highlighted the ability of -syn to cross the BBB and its contribution in the accumulation of -syn pool in the brain, further clearance from the brain across the BBB occurs through LRP1-mediated transcytosis

There is also some limited evidence suggesting that individuals who carry certain polymorphisms in genes involved in vitamin C transport and detoxification mechanisms may have lower plasma vitamin C concentrations even with high vitamin C intakes (see also Vascular complications of diabetes mellitus) (reviewed in 27)

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